Double-Hit Primary Plasma Cell Leukemia with IGH/MYC and IGH/CCND1 Translocations

Table 1

Development of cytogenetic aberrations over time during treatment.

Period	Karyotype Result
At onset	47, Y, t (X; 8; 14) (q24; q24; q32), t (11; 14) (q13; q32), +18 [2]/46, XY [6]
At first relapse (after Bd therapy)	51, Y, t (X; 8; 14) (q24; q24; q32), −5, t (11; 14) (q13; q32), +12,−17, +18 + 20, +4mar [1]/46, XY[5]
After IRd therapy	52, Y, t (X; 8; 14) (q24; q24; q32), +der (11)t (11; 14) (q13; q32), t (11; 14), +der (14)t (8; 14) (q24; q32),+18, +18, +18, +20 [4]/46, XY [3]