PML-RARA Fusion Transcripts Detectable 8 Months prior to Promyelocytic Blast Crisis in Chronic Myeloid Leukemia

Table 1

Peripheral blood, bone marrow, and conventional cytogenetic findings over time.

Time relative to CML diagnosis	Peripheral blood				Bone marrow		Conventional cytogenetics
	WBC (×10^3/μL)	Hemoglobin (g/dL)	Platelets (×10^3/μL)	Promyelocytes (%)	Cellularity	Promyelocytes (%)
−7 years	7.2	14.9	200	0	Normocellular	<1	46, XY [20]
0	44	14.8	225	0	>95%	1	46, XY, t(9;22)(q34;q11.2) [20]
10 months	3	13.2	106	0	N/A	1	46, XY, t(9;22)(q34;q11.2) [1]/46, XY [19]
17 months	2	12.8	56	44	70%	67	46, XY, t(9;22)(q34;q11.2), t(15;17)(q22;q21) [18]/46, XY [2]

The trephine biopsy was suboptimal and unable to be accessed for cellularity. Reference ranges: WBC 4.8–10.8 × 10³/μL, hemoglobin 14.0–18.0 g/dL, platelets 160–360 × 10³/μL. CML, chronic myeloid leukemia; WBC, white blood count; N/A, not applicable.