T-Cell Large Granular Lymphocytic Leukemia with Extremely Rare Immunophenotype (CD4/CD8 Double-Positive) Followed by Multiple Myeloma Diagnosis

<div>BM aspirate smear (Wright’s stain, 100x) revealing ∼18% myeloma plasma cells with a few atypical binucleated forms (a). FCM analysis on BM aspirate (b) showing a population of monotypic plasma cells ∼5% expressing CD45, CD38, and CD138 with cytoplasmic kappa light chain restriction and aberrant expression of CD56 and CD117. The plasma cells show no significant expression of CD20. LGLs included the same population of CD4/CD8 double-positive cells (∼2%) (red arrow) showing a dimmer expression of CD4 and CD7.</div>

Case Reports in Hematology

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Figure 2: T-Cell Large Granular Lymphocytic Leukemia with Extremely Rare Immunophenotype (CD4/CD8 Double-Positive) Followed by Multiple Myeloma Diagnosis 

Figure 2 | T-Cell Large Granular Lymphocytic Leukemia with Extremely Rare Immunophenotype (CD4/CD8 Double-Positive) Followed by Multiple Myeloma Diagnosis 