Combined Ruxolitinib and Venetoclax Treatment in a Patient with a BCR-JAK2 Rearranged Myeloid Neoplasm

Figure 2

Fluorescent in situ hybridization with probes for BCR (22q11.2, green signal) and ABL1 (9q34.1, red signal) was negative for a BCR-ABL1 rearrangement. However, a third signal for the BCR probe (green signal, arrow) was observed, suggesting partial or complete gain of chromosome 22 or a translocation that involves BCR with a partner gene other than ABL1. Additional testing with a probe for JAK2 (9p24.1, not shown) suggested the presence of a BCR-JAK2 fusion, which was confirmed with RNA sequencing.