Case Report

Combined Ruxolitinib and Venetoclax Treatment in a Patient with a BCR-JAK2 Rearranged Myeloid Neoplasm

Table 1

Summary of the literature regarding described phenotype, treatment, and response duration of patients with a BCR-JAK2 fusion.

ReferenceAgeSexDiseaseTreatmentFollow-up

Griesinger et al. [2]63FCML-like MPD, myeloid blast crisisImatinib, hydroxyurea, interferon-alphaComplete hematological response. 20 months after diagnosis, she developed myeloid blast crisis and died.
Kantarcioglu et al. [3]64FMDSNot describedDied 3 months after diagnosis
Cuesta-Domínguez et al. [4]58MB-ALLNot describedNot described
Cirmena et al. [5]67FAMLNot describedNot described
Tirado et al. [6]14MB-ALLNot describedNot described
Snider et al. [7]59MMPN with eosinophilia, MPALHydroxyurea, chemotherapy, allo-SCTTransformation to MPAL 12 months after diagnosis. No evidence of disease 30 days after allo-SCT.
Elnaggar et al. [8]84MCML-like MPDImatinibLost to follow-up
Schwaab et al. [10]n/an/aMyeloid neoplasmRuxolitinib 20 mg BID, allo-SCTComplete hematological and cytogenetic remission on ruxolitinib. Relapsed after 18 months upon which referred for allo-SCT.
Schwaab et al. [11]69MMDS/MPNRuxolitinib 20 mg BID, allo-SCTComplete hematological, cytogenetic, and molecular response. AlloSCT while in remission
He et al. [14]36FMPN with eosinophiliaDasatinib, allo-SCTNo response of dasatinib. No evidence of disease 18 months after allo-SCT.
Bellesso et al. [15]54MBCR-ABL- CMLImatinib, dasatinib, allo-SCTNo response of imatinib or dasatinib. Died of aGvHD 53 days after allo-SCT
Impera et al. [16]49FMPN-unclassifiableImatinib, dasatinib peg-interferonNo initial response with imatinib or dasatinib. Partial hematological response with peg-interferon
Lane et al. [17]44MAtypical CML with leukemia cutisNot describedNot described
Thakral et al. [18]31MMPN with eosinophiliaHydroxyurea, allo-SCTNo evidence of disease three months posttransplantation

CML, chronic myeloid leukemia; MPD, myeloproliferative disorder; MDS, myelodysplastic syndrome; B-ALL, B-cell acute lymphoblastic leukemia; AML, acute myeloid leukemia; MPN, myeloproliferative neoplasm; MPAL, mixed phenotype acute leukemia; allo-SCT, allogeneic stem cell transplantation; BID, twice a day; aGvHD, acute graft-versus-host disease; F, female; M, male.