Case Reports in Hematology

Case Report

The Combination of Interferon-Alpha and Ponatinib Enables Faster and Deeper Molecular Responses in Patient with De Novo Blast Crisis of CML: Interferon-Alpha May Return as a CML Treatment

Table 1

Laboratory findings on admission.
Peripheral blood
WBC25, 200/μl
Blast78%
Stab0%
Seg1%
Lymph20%
Mono0%
Eo1%
Baso0%
RBC220 × 10e4/μl
Hb7.1 g/dl
Ht20.90%
Plt2.2 × 10e4/μl
NAP-R89% (61∼99)
NAP-S381 (170∼355)
Coagulation
PT13.3 sec
APTT34.8 sec
Fibrinogen321 mg/dl
FDP3.5 μg/μl
D-dimer1.2 μg/ml
AT-III110%
Biochemistry
TP7.0 g/dl
Alb3.9 g/dl
Tbili0.4 mg/dl
Dbili0.1 mg/dl
AST21 U/l
ALT23 U/l
LDH248 U/l
γGTP75 U/l
BUN14.7 mg/dl
Cr0.93 mg/dl
UA5.4 mg/dl
eGFR62.5 ml/min
Glu71 mg/dl
CRP1.8 mg/dl
Ferritin1011.6 ng/ml
Bone marrow
NCC28.8 × 10e4/μl
Mgk+
Blast98.80%
M/E165
G-Band karyotype of bone marrow 
46, XY, t(9; 22) (q34; q11.2) [16] 
46, XY [4] 
BCR-ABL1 transcripts 
Major BCR-ABL1 18 × 10e5, HLA-DR+ 
Immunophenotype of blasts in bone marrow 
CD34+, HLA = DR+, MPO−, CD3−, TdT+, CD19+, CD79a+, CD13± 
Abbreviation: WBC, white blood cells; blast, myeloblast; myelo, myelocytes; meta, metamyelocytes; stab, stab cells; seg, segmented cells; lym, lymphocytes; mono, monocytes; eo, eosinophiles; baso, basophiles; Hb, hemoglobin; Ht, hematocrit; Plt, platelet; NAP-rate, neutrophil alkaline phosphatase activities-rate; NAT-score, neutrophil alkaline phosphatase activities-score; NCC, nuclear cell counts; Mgk, megakaryocytes; M/E, myeloid erythroid ratio; PT, prothrombin time; APTT, activated partial thromboplastin time; FDP, fibrin/fibrinogen degradation product; AT-III, antithrombin-III.