Pulmonary Lymphangitic Spread of Multiple Myeloma as Early Relapse after Autologous Stem Cell Transplantation

Table 1

Summary of case reports with myelomatous lung involvement and their outcomes.

Case reports	Age and gender	Diagnostic modality	Subtype of myeloma	Cytogenetics	EMD involvement of the lung	Treatments	Status
Marmor et al. [13]	65, F	Lung biopsy	IgG kappa	NA	At initial diagnosis of MM	None	Expired
Nitu et al. [14]	60, M	BAL	IgG	NA	At initial diagnosis of MM	None	Unknown
Yuan et al. [15]	58, M	BAL	IgG kappa	t (11; 14) (q13; q32) and del 13q14.3	4 years after ASCT	Induction: vincristine, adriamycin, and dexamethasone (VAD) followed by ASCT; while hospitalized: thalidomide, dexamethasone, bortezomib, and doxorubicin.	Expired
Kushwaha et al. [18]	60, M	Lung biopsy and BMBx	IgG	NA	At initial diagnosis of MM	None	Expired
Sahin Balcik et al. [18]	62, M	Lung biopsy	IgA kappa	Del(13q), hypodiploidy	At initial diagnosis of MM	Vincristine, adriamycin, dexamethasone (VAD)	Expired
Ravinet et al. [17]	61, M	Lung tissue autopsy	IgG kappa	t (4; 14)	6 months after diagnosis of MM; EMD lung within 2 months of ASCT	Induction: bortezomib, thalidomide, and dexamethasone followed by ASCT	Expired
Lok et al. [16]	64, M	Chest wall mass biopsy and BAL	Lambda light chain	NA	5 months after diagnosis of MM	NA	Expired
Rai et al. [19]	55, F	CT guided lung biopsy, BMBx	NR	NA	At initial diagnosis of MM	NA	NR
Abhishek et al. [20]	58, M	Lung biopsy	NR	NA	1 year after diagnosis of MM	Induction therapy: bortezomib, thalidomide, and dexamethasone. Treatment for relapse not reported.	NR
Shah et al. [21]	60, M	CT guided FNAC of lung mass, BMBx	IgG	NA	At initial diagnosis of MM	Melphalan, prednisone	Unknown
Furuncuoglu et al. [22]	42, M	CT guided lung biopsy	Lambda light chain	NA	At initial diagnosis of MM	NA	Unknown

NA, not available; NR, not reported; BAL, bronchoalveolar lavage; BMBx, bone marrow biopsy; ASCT, autologous stem cell transplant; CT, computed tomography; EMD, extramedullary disease.