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| Patient | Age | Gender | Diagnosis | Stage of disease | Date of bone marrow biopsy compared to most recent COVID PCR positivity | Bone marrow findings | Full blood count | Coagulation results | Outcome |
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| Case described | 70 | Female | AML | In CR1, after 2 cycles of induction chemotherapy (CPX-351) | After 8 days | Suppressed myelopoiesis. No excess of blasts. Hyperplastic erythropoiesis with stress-type arrangement. Young forms appear megaloblastic. Reduced megakaryocytes with atypia. Many foamy histiocytes | Hb 86 g/L, WCC 2.36 × 109/L, neutrophils 1.10 × 109/L, lymphocytes 0.74 × 109/L, monocytes 0.43 × 109/L, platelets 15 × 109/L | PT NA, APTT NA, fibrinogen NA, D-dimer NA | Now COVID-19 negative and has engrafted post-allogeneic stem cell transplant |
| 2 | 68 | Female | Multiple myeloma | Diagnosis | N/A | Severely reduced megakaryocytes, erythropoiesis, and myelopoiesis. >90% blastoid plasma cells | Hb 76 g/L, WCC 7.88 × 109/L, neutrophils 2.44 × 109/L, lymphocytes 3.58 × 109/L, monocytes 1.79 × 109/L, platelets 129 × 109/L | PT 16.2 seconds, APTT 28.8 seconds, fibrinogen NA, D-dimer NA | Now COVID-19 negative. Ongoing induction chemotherapy |
| 2 | 68 | Female | Multiple myeloma | Midthird cycle of chemotherapy | After 3 days | Globally reduced megakaryocytes with nonspecific atypia. Normal myelopoiesis with scattered hyperplastic areas. Normal erythropoiesis with scattered hyperplastic areas. Postnecrotic scarring with numerous histiocytes and a few clusters of histiocytes. Scattered residual blastoid plasma cells | Hb 89 g/L, WCC 4.2 × 109/L, neutrophils 2.99 × 109/L, lymphocytes 0.71 × 109/L, monocytes 0.47 × 109/L, platelets 13 × 109/L | PT 12.65 seconds, APTT 28.35 seconds, fibrinogen 4.00 g/L, D-dimer 2034 ng/ml | Now COVID-19 negative. Ongoing induction chemotherapy |
| 3 | 47 | Male | Aplastic anaemia | Diagnosis | After 1 day | Myelopoiesis almost completely absent. Erythropoiesis almost completely absent. Megakaryocytes completely absent. Scattered increase in mast cells, which are very granulated. Less than 5% bone marrow cellularity | Hb 56 g/L, WCC 3.98 × 109/L, neutrophils 0.5 × 109/L, lymphocytes 3.36 × 109/L, monocytes 0.11 × 109/L, platelets 23 × 109/L | PT 12.7 seconds, APTT 27.8 seconds, fibrinogen NA, D-dimer NA | Now COVID-19 negative. Awaiting allogeneic stem cell transplant for very severe aplastic anaemia |
| 4 | 88 | Male | MDS with multilineage dysplasia | Diagnosis | After 2 days | Suppressed left shifted myelopoiesis. 1–2% blasts. Dysplastic, hyperplastic erythropoiesis. Increased megakaryocytes with numerous dysplastic micromegakaryocytes. Moderate excess of mast cells that are degranulated | Hb 78 g/L, WCC 3.7 × 109/L, neutrophils 0.48 × 109/L, lymphocytes 2.90 × 109/L, monocytes 0.32 × 109/L, platelets 32 × 109/L | PT 14.6 seconds, APTT NA, fibrinogen NA, D-dimer NA | Now COVID-19 negative. Ongoing support with G-CSF and erythropoietin |
| 5 | 79 | Male | Primary myelofibrosis | Suspected disease progression | After 7 days | Suppressed myelopoiesis. 8% blasts. Dysplastic erythropoiesis. Increased megakaryocytes which look dysplastic, including micromegakaryocytes. Diffuse stromal fibrosis, Bauermeister 3+ | Hb 70 g/L, WCC 3.21 × 109/L, neutrophils 1.76 × 109/L, lymphocytes 0.91 × 109/L, monocytes 0.52 × 109/L, platelets 56 × 109/L | PT 15.0 seconds, APTT 29.9 seconds, fibrinogen 4.17 g/L, D-dimer 1519 ng/ml | COVID-19 negative on discharge. Died of progressive disease |
| 6 | 41 | Male | Nodular lymphocyte predominant Hodgkin lymphoma | 3 months after BEAM autograft | Before 4 days | Normal myelopoiesis. Normal erythropoiesis. Reduced megakaryocytes but no dysplastic features. Extensive stromal oedema and expansion of loose pathological extracellular matrix. No pathological lymphoid infiltrate | Hb 123 g/L, WCC 3.36 × 109/L, neutrophils 2.80 × 109/L, lymphocytes 0.43 × 109/L, monocytes 0.13 × 109/L, platelets 17 × 109/L | PT 15.8 seconds, APTT 26.8 seconds, fibrinogen 5.31 g/L, D-dimer 11380 ng/ml | Died of COVID-19 |
| 7 | 65 | Female | AML with MDS-related changes | 6 weeks after allogeneic stem cell transplant | Before 13 days | Chaotic myelopoiesis. Normal erythropoiesis. Increased megakaryocytes, which are mostly small and dysplastic. 30–40% blasts. Widespread stromal oedema | Hb 85 g/L, WCC 1.45 × 109/L, neutrophils 0.61 × 109/L, lymphocytes 0.5 × 109/L, monocytes 0.28 × 109/L, platelets 33 × 109/L | PT NA, APTT NA, fibrinogen NA, D-dimer NA | Died of disease relapse |
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