Case Report

A Rare Case of Midostaurin-Associated Sweet’s Syndrome

Table 2

Diagnostic criteria for Sweet’s syndrome.

Major criteriaMinor criteria

Abrupt onset of painful erythematous papules, nodules, or plaquesFever >38°C

Histopathological findings of dense neutrophilic infiltrates without evidence of leukocytoclastic vasculitisAssociation with hematologic or visceral malignancy, inflammatory disease, or pregnancy, or preceded by upper respiratory tract infection, gastrointestinal infection, or vaccination

Dramatic response to treatment with systemic steroids or potassium iodide

Abnormalities in laboratory tests (three of four): erythrocyte sedimentation rate >20 mm/h; high C-reactive protein; leukocytes >8000, with >70% neutrophils