Efficacy of CRISPR-Based Gene Editing in a Sickle Cell Disease Patient as Measured through the Eye

Figure 1

OCT-A images of the left eye of the HbSS patient, imaged across 3 imaging visits. The left column shows averaged OCT-A images from the first visit, the middle column from the second visit, and the right column from the third visit. The first and second rows show the averaged OCT-A images from the first and second sessions, respectively, taken 1 hour apart during each visit. The third row of images represents the computed intermittent perfusion maps. Nonperfusion between sessions is highlighted in red, and reperfusion between sessions is highlighted in cyan. The sum of the nonperfusion and reperfusion percent densities equals the intermittent perfusion index (IPI).