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Case Reports in Hepatology
Volume 2012 (2012), Article ID 138381, 3 pages
http://dx.doi.org/10.1155/2012/138381
Case Report

Reversal of Jaundice in Two Patients with Inoperable Cholangiocarcinoma Treated with Cisplatin and Gemcitabine Combination

1Department of Medical Oncology, Regionaal Ziekenhuis SINT MARIA, Ziekenhuislaan 100, 1500 Halle, Belgium
2Department of Gastroenterology, Regionaal Ziekenhuis SINT MARIA, Ziekenhuislaan 100, 1500 Halle, Belgium

Received 30 November 2011; Accepted 17 January 2012

Academic Editors: F. Pérez Roldán and H. Uchiyama

Copyright © 2012 Maarten Criel et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Two patients are presented with severe jaundice, due to inoperable cholangiocarcinoma. The chemotherapeutic approach in patients with severe jaundice is discussed. Many schedules of chemotherapy were developed in this tumor type with normal serum bilirubin. We report here the first successful use of cisplatin and gemcitabine combination chemotherapy in these patients. Tolerability was good and liver function tests gradually improved.