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Case Reports in Hepatology
Volume 2012 (2012), Article ID 793963, 3 pages
http://dx.doi.org/10.1155/2012/793963
Case Report

Biliary Adenofibroma with Carcinoma In Situ: A Rare Case Report

1Department of Surgery, Baylor College of Medicine, One Baylor Plaza, Suite 404D, Houston, TX 77030, USA
2Department of Pathology, St. Luke’s Episcopal Hospital, 6720 Bertner Avenue, Houston, TX 77030, USA
3Division of Abdominal Transplantation, Baylor College of Medicine, One Baylor Plaza, Suite 404D, Houston, TX 77030, USA

Received 2 July 2012; Accepted 2 August 2012

Academic Editors: D. Lorenzin and N. Terayama

Copyright © 2012 N. Thao T. Nguyen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This case report exhibits a rare biliary tumor within the liver of a 53-year-old Caucasian woman. This exophytic, multicystic, 6.5 × 5.0 cm mass was composed of complex tubulocystic structures lined by nonmucin-secreting, biliary epithelium embedded in fibrous stroma, consistent with biliary adenofibroma. This is the seventh case described in the literature. Multiple foci of high-grade dysplasia/carcinoma in situ were found with a microscopic focus of invasive carcinoma in review of the pathology, making this only the second case reporting malignant transformation. It is presented to illustrate the premalignant potential in a biliary epithelial tumor currently categorized as benign.