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Case Reports in Hepatology
Volume 2016, Article ID 2032714, 3 pages
Case Report

Hepatocellular Carcinoma with Prominent Intracytoplasmic Inclusions: A Report of Two Cases

1Department of Pathology, Cork University Hospital, Cork, Ireland
2Laboratory Medicine, Peterborough Regional Health Centre, Peterborough, ON, Canada

Received 29 July 2016; Revised 22 September 2016; Accepted 27 September 2016

Academic Editor: Zu-Yau Lin

Copyright © 2016 Adeline R. Chelliah and Jasim M. Radhi. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Hepatocellular carcinoma (HCC) is the commonest primary malignant neoplasm of the liver in most countries with a notoriously poor prognosis. Variation in global incidence is well-recognized and the occurrence of HCC is linked to several established environmental, dietary, and lifestyle factors. HCC demonstrates morphological heterogeneity both within the same tumor and from patient to patient. Differing architectural patterns and cytological variants may be seen. Inclusion bodies are believed to represent organized structures of proteins which contribute to their pathogenesis and share several constituents like chaperones, p62, ubiquitin, and Valosin containing protein. The various hepatocyte cytoplasmic inclusions described in HCC include Mallory-Denk bodies (MDBs), hyaline bodies (HBs), glycogen, fat, fibrinogen, alpha 1 antitrypsin (AAT), and ground glass. MDBs are the most common inclusions seen in hepatocellular carcinomas. The two cases shared intracytoplasmic inclusions which are characterized by larger sizes and present in every section examined. These exhibited features of MDBs and HBs present in most tumor cells, further supporting close relationship.