Hepatotoxicity due to Clindamycin in Combination with Acetaminophen in a 62-Year-Old African American Female: A Case Report and Review of the Literature

Table 1

Cases of clindamycin hepatotoxicity in adults searched on PubMed till date.

Author	Year	Age	Sex	Reason for taking clindamycin	Presentation	Biopsy	Liver enzymes (ALT, AST, ALP)	Trend of liver enzymes	Evolution of liver injury after cessation of clindamycin	Treatment
[5]	1977	57	M	Endocarditis	N/A	H	I	DW	Two patients had hepatotoxicity which resolved rapidly after clindamycin was stopped	CS
[4]	1974	18	M	Endocarditis and pulmonary abscesses	N/A	HC/C	I	DW	Repeat liver biopsy after 12 days of stopping clindamycin showed significant resolution of SGOT level; SGOT returned to normal in 30 days	CS
[2]	1994	67	M	Skin abscess	Jaundice	C	I	DW	Persistence of duct paucity	CS
[3]	2007	42	F	Dental infection	Jaundice, pruritus	NP	I	DW	LFTs returned to normal after 8 weeks	CS
[1]	2009	52	F	Cerebral abscess	N/A	NP	I	DW	Complete resolution	CS
[6]	2009	48	F	Bronchial infection	Jaundice, pruritus	C	I	DW	Stevens Johnson Syndrome and intrahepatic cholestasis simultaneously	CS
[7]	2013	73	M	Pneumonia	Jaundice	NP	I	DW	Developed liver failure	CS
[8]	2015	75	F	Urinary tract infection	Jaundice	C	I	DW	At 4 weeks’ follow-up, biochemical tests returned to baseline normal values	CS
Present case report	2016	62	F	Dental infection	Accidental finding	NP	I	DW	Patients LFTs gradually returned to normal; patient is being followed up in the clinic	CS

H: hepatocellular, C: cholestasis, CS: clindamycin stopped, NP: not performed, DW: downward trend, and I: increased.