Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Hepatology
Volume 2017, Article ID 2705131, 3 pages
https://doi.org/10.1155/2017/2705131
Case Report

Should Serum Protein Electrophoresis Be a Surrogate for Liver Biopsy in Some Cases of Alpha1 Antitrypsin Deficiency?

1Internal Medicine Department, Hematology Division, Botucatu Medical School, Universidade Estadual Paulista (UNESP), Botucatu, SP, Brazil
2Pathology Department, Botucatu Medical School, Universidade Estadual Paulista (UNESP), Botucatu, SP, Brazil
3Internal Medicine Department, Gastroenterology Division, Botucatu Medical School, Universidade Estadual Paulista (UNESP), Botucatu, SP, Brazil

Correspondence should be addressed to Fernando Gomes Romeiro; moc.liamg@oriemorgf

Received 3 April 2017; Revised 5 August 2017; Accepted 23 August 2017; Published 28 September 2017

Academic Editor: Julio M. F. Chebli

Copyright © 2017 Newton Key Hokama et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Most patients with alpha1 antitrypsin deficiency do not receive this diagnosis until developing severe complications, in particular when respiratory symptoms are absent. This is a reason for making alpha1 antitrypsin deficiency a possible diagnosis among patients with cryptogenic cirrhosis or other conditions of liver disease without a clear etiology. In this report, a case of cryptogenic cirrhosis is presented, showing the role of serum protein electrophoresis in the diagnosis, which was made before liver biopsy. Therefore, the possibility of using a typical pattern of serum protein electrophoresis as a surrogate for liver biopsy in alpha1 antitrypsin deficiency is discussed.