Early Onset of Tenofovir-Related Fanconi Syndrome in a Child with Acute Hepatitis B: A Case Report and Systematic Review of Literature

Table 1

Review of cases of TDF-associated Fanconi Syndrome during Hepatitis B therapy.

	Age	Sex	TDF-treatment duration	Risk factor	Serum creatinine (mg/dl)	eGFR (ml/min)	Serum phosphate; (mg/dl)	Serum bicarbonate (mmol/L)	Uric Acid (mg/dl)	Phosphate fractional excretion (%)	Glycosuria; (mg/dl)	Proteinuria (g/24 h)
Murray et al. [10]	39	M	24 months	Adefovir exposure	1.44	59	1.86	n/a	3.5	n/a	yes	0.6
Murray et al. [10]	54	M	24 months	Hypertension	1.53	51	2.1	n/a	1.34	elevated	n/a	0.2
Magalhães-Costa et al. [11]	82	M	6 months	Adefovir exposure, diabetes	n/a	n/a	1.1	13.9	1.7	65.8%	yes	yes
Gracey et al. [12]	58	M	42 months	Adefovir exposure	1.32	55	2.1	19.3	n/a	n/a	500	0.5
Gracey et al. [12]	62	M	45 months	Hypertension	3.35	18	1.7	19.5	n/a	n/a	400	n/a
Viganò et al. [13]	44	F	3 months	Diabetes	3.22	20	2.6	11	2.5	elevated	n/a	yes
Samarkos et al. [14]	58	M	12 months	Adefovir exposure, hypertension	1.45	n/a	1.4	17.1	n/a	elevated	500	0.96
Hwang et al. [15]	40	M	36 months	No	1.5	58.6	1.3	n/a	1.9	41%	200	0.3
Our case	12	M	5 months	Ifosfamide, Cisplatin	0.47	70	1.9	n/a	n/a	56%	70	0.2

MDRD formula; dipstick. maximal transport of phosphate reabsorption to the glomerular filtration rate transport (TmP/GFR): 0.008 mg/dl; /GFR: 0.66 mmol/L.