Fatal Invasive Cryptococcal Infection in an HIV-Negative Elderly Patient with Decompensated Hepatic Cirrhosis

Table 2

Cirrhosis-related cryptococcosis; Japanese experiences.

	Reference	Age/Gender	Causes of liver cirrhosis	Symptoms	Cryptococcal; infection	Treatment	Outcome; (survival)
1	Nakamura 2016	68/F	PBC	fever	peritonitis; fungemia	MCFG	Died; (32 days)
2	Haga 2015	59/M	HCV	dyspnea; PE	pulmonary,; MRSA	surgery	Died; (8 days)
3	Hokari 2010	58/F	PBC	diarrhea	systemic	VCM	Died; (16 days)
4	Akiyama 2010	64/M	Alcohol	seizure	meningitis	AMPH-B; F-FLCZ	Died; (23 days)
5	Mitomi 2004	43/M	Alcohol	headache; fever,; general malaise	meningitis	FLCZ; AMPH-B	Died; (57 days)
6	Touge 1999	60/M	HBV	headache; nausea	meningitis	FLCZ	Alive
7	Arata 1996	58/M	NA	fever; cavernous lung mass	pulmonary/; meningitis	FLCZ	Alive; (22 days+)
8	Miyazaki 1993	70/M	HCV	disturbed consciousness	meningitis	FCLZ	Alive
9	Yoshizawa 1992	58/M	NA	fever; dyspnea	fungemia; systemic	antibiotics	Died
10	Okazaki 1990	43/M	NA	disturbed consciousness	systemic	NA	Died
11	Yamamoto 1990	32/M	NA	fever; headache; hematemesis	meningitis	5-FC; MCZ	Alive
12	Present case	82/F	HBV	general malaise; hypotension; coma	fungemia	none	Died; (4 days)

Abbreviations. PBC=primary biliary cirrhosis, HBV=hepatitis B virus, HCV=hepatitis C virus, NA=not available, PE=pleural effusion, MRSA= Methicillin-resistant Staphylococcus aureus, MCFG=Micafungin, VCM=Vancomycin, AMPH-B=Amphotericin-B, F-FLCZ= fosfluconazole, FLCZ= fluconazole, 5-FC= flucytosine, MCZ= miconazole.