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Case Reports in Hepatology
Volume 2018 (2018), Article ID 6483605, 5 pages
https://doi.org/10.1155/2018/6483605
Case Report

Hepatotoxicity Associated with Use of the Weight Loss Supplement Garcinia cambogia: A Case Report and Review of the Literature

1Nazih Zuhdi Transplant Institute, INTEGRIS Baptist Medical Center, 3300 NW Expressway, Oklahoma City, OK 73112, USA
2Department of Internal Medicine, Coney Island Hospital, 2601 Coney Island Avenue, Brooklyn, NY 11235, USA
3Division of Gastroenterology and Hepatology, Louisiana State University Health Sciences Center, Shreveport, LA 71103, USA
4Department of Gastroenterology and Hepatology, University of Nebraska Medical Center, 982000 Nebraska Medical Center, Omaha, NE 68198, USA

Correspondence should be addressed to Jiten P. Kothadia; moc.liamg@netij.aidahtok

Received 28 October 2017; Revised 3 January 2018; Accepted 31 January 2018; Published 12 March 2018

Academic Editor: Fumio Imazeki

Copyright © 2018 Jiten P. Kothadia et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Y.-J. Kim, M.-S. Choi, Y. B. Park, S. R. Kim, M.-K. Lee, and U. J. Jung, “Garcinia cambogia attenuates diet-induced adiposity but exacerbates hepatic collagen accumulation and inflammation,” World Journal of Gastroenterology, vol. 19, no. 29, pp. 4689–4701, 2013. View at Publisher · View at Google Scholar · View at Scopus
  2. R. Corey, K. T. Werner, A. Singer et al., “Acute liver failure associated with Garcinia cambogia use,” Annals of Hepatology, vol. 15, no. 1, pp. 123–126, 2016. View at Publisher · View at Google Scholar · View at Scopus
  3. E. X. Zheng and V. J. Navarro, “Liver Injury from Herbal, Dietary, and Weight Loss Supplements: a Review,” Journal of Clinical and Translational Hepatology, vol. 3, no. 2, pp. 93–98, 2015. View at Publisher · View at Google Scholar
  4. M. García-Cortés, M. Robles-Díaz, A. Ortega-Alonso, I. Medina-Caliz, and R. J. Andrade, “Hepatotoxicity by Dietary Supplements: A tabular Listing and Clinical Characteristics,” International Journal of Molecular Sciences, vol. 17, no. 4, article no. 537, 2016. View at Publisher · View at Google Scholar · View at Scopus
  5. V. J. Navarro, H. Barnhart, H. L. Bonkovsky et al., “Liver injury from herbals and dietary supplements in the U.S. Drug-Induced Liver Injury Network,” Hepatology, vol. 60, no. 4, pp. 1399–1408, 2014. View at Publisher · View at Google Scholar · View at Scopus
  6. A. Lobb, “Hepatoxicity associated with weight-loss supplements: A case for better post-marketing surveillance,” World Journal of Gastroenterology, vol. 15, no. 14, pp. 1786-1787, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. J. Melendez-Rosado, D. Snipelisky, G. Matcha, and F. Stancampiano, “Acute hepatitis induced by pure garcinia cambogia,” Journal of Clinical Gastroenterology, vol. 49, no. 5, pp. 449-450, 2015. View at Publisher · View at Google Scholar · View at Scopus
  8. J. Heo, M. Seo, H. Park et al., “Gut microbiota Modulated by Probiotics and Garcinia cambogia Extract Correlate with Weight Gain and Adipocyte Sizes in High Fat-Fed Mice,” Scientific Reports, vol. 6, Article ID 33566, 2016. View at Publisher · View at Google Scholar · View at Scopus
  9. G. Danan and R. Teschke, “RUCAM in drug and herb induced liver injury: the update,” International Journal of Molecular Sciences, vol. 17, no. 1, p. 14, 2016. View at Publisher · View at Google Scholar
  10. T. Stevens, A. Qadri, and N. N. Zein, “Two patients with acute liver injury associated with use of the herbal weight-loss supplement hydroxycut [7],” Annals of Internal Medicine, vol. 142, no. 6, pp. 477-478, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. F. J. Jones and A. H. Andrews, “Acute liver injury associated with the herbal supplement hydroxycut in a soldier deployed to Iraq,” American Journal of Gastroenterology, vol. 102, no. 10, pp. 2357-2358, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. J. Laczek and M. Duncan, “Three cases of acute hepatitis in patients taking Hydroxycut (R) bodybuilding supplement,” in American Journal of Gastroenterology, Nature Publishing Group, New York, NY, USA, 2008. View at Google Scholar
  13. L. Dara, J. Hewett, and J. K. Lim, “Hydroxycut hepatotoxicity: A case series and review of liver toxicity from herbal weight loss supplements,” World Journal of Gastroenterology, vol. 14, no. 45, pp. 6999–7004, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Shim and S. Saab, “Severe hepatotoxicity due to hydroxycut: A case report,” Digestive Diseases and Sciences, vol. 54, no. 2, pp. 406–408, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. T.-L. Fong, K. C. Klontz, A. Canas-Coto et al., “Hepatotoxicity due to hydroxycut: A case series,” American Journal of Gastroenterology, vol. 105, no. 7, pp. 1561–1566, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. T. Sharma, L. Wong, N. Tsai, and R. D. Wong, “Hydroxycut(®) (herbal weight loss supplement) induced hepatotoxicity: a case report and review of literature.,” Hawaii Medical Journal, vol. 69, no. 8, pp. 188–190, 2010. View at Google Scholar · View at Scopus
  17. J. L. Lee, H. P. Shin, J. W. Jeon, J. M. Cha, K. R. Joo, and J. I. Lee, “A Case of Toxic Hepatitis by Weight-Loss Herbal Supplement Containing Garcinia cambogia,” Soonchunhyang Medical Science, vol. 20, no. 2, pp. 96–98, 2014. View at Publisher · View at Google Scholar
  18. R. J. Smith, C. Bertilone, and A. G. Robertson, “Fulminant liver failure and transplantation after use of dietary supplements,” Medical Journal of Australia, vol. 204, no. 1, pp. 30–32.e1, 2016. View at Publisher · View at Google Scholar · View at Scopus
  19. K. E. Lunsford, A. S. Bodzin, D. C. Reino, H. L. Wang, and R. W. Busuttil, “Dangerous dietary supplements: Garcinia cambogia-Associated hepatic failure requiring transplantation,” World Journal of Gastroenterology, vol. 22, no. 45, pp. 10071–10076, 2016. View at Publisher · View at Google Scholar · View at Scopus
  20. D. Kaswala, S. Shah, N. Patel, S. Raisoni, and S. Swaminathan, “Hydroxycut-induced liver toxicity,” Annals of Medical and Health Sciences Research, vol. 4, no. 1, pp. 143–145, 2014. View at Publisher · View at Google Scholar
  21. L. O. Chuah, S. K. Yeap, W. Y. Ho, B. K. Beh, and N. B. Alitheen, “In vitro and in vivo toxicity of garcinia or hydroxycitric acid: A review,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 197920, 12 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. D. L. Clouatre and H. G. Preuss, “Hydroxycitric acid does not promote inflammation or liver toxicity,” World Journal of Gastroenterology, vol. 19, no. 44, pp. 8160–8162, 2013. View at Publisher · View at Google Scholar · View at Scopus
  23. S. B. Heymsfield, D. B. Allison, J. R. Vasselli, A. Pietrobelli, D. Greenfield, and C. Nunez, “Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial,” The Journal of the American Medical Association, vol. 280, no. 18, pp. 1596–1600, 1998. View at Publisher · View at Google Scholar · View at Scopus
  24. I. Onakpoya, S. K. Hung, R. Perry, B. Wider, and E. Ernst, “The use of Garcinia extract (hydroxycitric acid) as a weight loss supplement: a systematic review and meta-analysis of randomised clinical trials,” Journal of Obesity, vol. 2011, Article ID 509038, 9 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus