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Case Reports in Hepatology
Volume 2018, Article ID 9324872, 3 pages
https://doi.org/10.1155/2018/9324872
Case Report

Castleman’s Disease and Posttransplant Lymphoproliferative Disorder after Liver Transplant: 3-Year Follow-Up

1Division of Gastroenterology & Hepatology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA
2Department of Hematology/Oncology, University of Nebraska Medical Center, Omaha, NE, USA

Correspondence should be addressed to Lokesh K. Jha; moc.liamg@ahjlrd

Received 29 September 2017; Revised 14 December 2017; Accepted 1 January 2018; Published 28 January 2018

Academic Editor: Mauro Vigano

Copyright © 2018 Lokesh K. Jha et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A 59-year-old male with a history of hepatitis C cirrhosis and history of hepatitis B exposure presented 8 months after orthotopic liver transplant (LT) with fever, fatigue, myalgia, night sweats, nonproductive cough, and shortness of breath. Bone marrow biopsy for pancytopenia was positive for Epstein-Barr virus (EBV) DNA. Lymph node biopsy for lymphadenopathy on imaging showed human herpes virus 8 (HHV8) associated Castleman’s disease. Treatment included valganciclovir, rituximab, and prednisone taper with eventual discontinuation. Quantitative HHV8 DNA was initially 611,000 DNA copies/mL and was later undetectable at 6 months following treatment and remained undetectable at 3-year follow-up.