Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Hepatology
Volume 2018 (2018), Article ID 9793868, 5 pages
https://doi.org/10.1155/2018/9793868
Case Report

Postinfantile Giant Cell Hepatitis with Features of Acute Severe Autoimmune Hepatitis Probably Triggered by Diclofenac in a Patient with Primary Myelofibrosis

1Department of Medicine and Research Laboratory of Internal Medicine, School of Medicine, University of Thessaly, Larissa, Greece
2Department of Pathology, Medical School, University of Thessaly, Larissa, Greece

Correspondence should be addressed to George N. Dalekos; rg.htu.dem@sokelad

Received 10 October 2017; Revised 11 January 2018; Accepted 11 February 2018; Published 11 March 2018

Academic Editor: Fumio Imazeki

Copyright © 2018 Pinelopi Arvaniti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Torbenson, J. Hart, M. Westerhoff et al., “Neonatal giant cell hepatitis: Histological and etiological findings,” The American Journal of Surgical Pathology, vol. 34, no. 10, pp. 1498–1503, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. C. Bihari, A. Rastogi, and S. K. Sarin, “Postinfantile giant cell hepatitis: an etiological and prognostic perspective,” Hepatitis Research and Treatment, vol. 2013, Article ID 601290, 7 pages, 2013. View at Publisher · View at Google Scholar
  3. S. J. Johnson, J. Mathew, R. N. M. MacSween, M. K. Bennett, and A. D. Burt, “Post-infantile giant cell hepatitis: Histological and immunohistochemical study,” Journal of Clinical Pathology, vol. 47, no. 11, pp. 1022–1027, 1994. View at Publisher · View at Google Scholar · View at Scopus
  4. K. Devaney, Z. D. Goodman, and K. G. Ishak, “Postinfantile giant‐cell transformation in hepatitis,” Hepatology, vol. 16, no. 2, pp. 327–333, 1992. View at Publisher · View at Google Scholar · View at Scopus
  5. J. Y. Lau, G. Koukoulis, G. Mieli-Vergani, B. C. Portmann, and R. Williams, “Syncytial giant-cell hepatitis—a specific disease entity?” Journal of Hepatology, vol. 15, no. 1-2, pp. 216–219, 1992. View at Publisher · View at Google Scholar
  6. J. Hartl, R. Buettner, F. Rockmann et al., “Giant cell hepatitis: An unusual cause of fulminant liver failure,” Zeitschrift für Gastroenterologie, vol. 48, no. 11, pp. 1293–1296, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. M. Iwai, M. Jo, M. Ishii, T. Mori, and Y. Harada, “Comparison of clinical features and liver histology in acute and chronic autoimmune hepatitis,” Hepatology Research, vol. 38, no. 8, pp. 784–789, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. J. Estradas, V. Pascual-Ramos, and B. Martínez, “Autoimmune hepatitis with giant-cell transformation,” Annals of Hepatology, vol. 1, pp. 68–70, 2009. View at Google Scholar
  9. K. Zachou, P. Muratori, G. K. Koukoulis et al., “Review article: autoimmune hepatitis—current management and challenges,” Alimentary Pharmacology & Therapeutics, vol. 38, no. 8, pp. 887–913, 2013. View at Publisher · View at Google Scholar · View at Scopus
  10. G. N. Dalekos, K. Zachou, C. Liaskos, and N. Gatselis, “Autoantibodies and defined target autoantigens in autoimmune hepatitis: An overview,” European Journal of Internal Medicine, vol. 13, no. 5, pp. 293–303, 2002. View at Publisher · View at Google Scholar · View at Scopus
  11. N. K. Gatselis, K. Zachou, G. K. Koukoulis, and G. N. Dalekos, “Autoimmune hepatitis, one disease with many faces: Etiopathogenetic, clinico-laboratory and histological characteristics,” World Journal of Gastroenterology, vol. 21, no. 1, pp. 60–83, 2015. View at Publisher · View at Google Scholar · View at Scopus
  12. E. M. Hennes, M. Zeniya, A. J. Czaja et al., “Simplified criteria for the diagnosis of autoimmune hepatitis,” Hepatology, vol. 48, no. 1, pp. 169–176, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. European Association for the Study of the Liver, “EASL clinical practice guidelines: autoimmune hepatitis,” Journal of Hepatology, vol. 63, no. 6, pp. 971–1004, 2015. View at Google Scholar
  14. R. T. Stravitz, J. H. Lefkowitch, R. J. Fontana et al., “Autoimmune acute liver failure: proposed clinical and histological criteria,” Hepatology, vol. 53, no. 2, pp. 517–526, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. K. Zachou, P. Arvaniti, N. Gatselis, K. Azariadi, G. Koukoulis, and G. Dalekos, “Prompt initiation of intravenous corticosteroids prevents deterioration of acute severe autoimmune hepatitis (AS-AIH) and the need for liver transplantation (LT),” Journal of Hepatology, vol. 66, no. 1, pp. S356–S357, 2017. View at Publisher · View at Google Scholar
  16. G. Koukoulis, G. Mieli-Vergani, and B. Portmann, “Infantile liver giant cells: Immunohistological study of their proliferative state and possible mechanisms of formation,” Pediatric and Developmental Pathology, vol. 2, no. 4, pp. 353–359, 1999. View at Publisher · View at Google Scholar · View at Scopus
  17. J. W. Fang, R. P. González-Peralta, S. K. Chong, G. M. Lau, G. M. Lau, and J. Y. Lau, “Hepatic expression of cell proliferation markers and growth factors in giant cell hepatitis: Implications for the pathogenetic mechanisms involved,” Journal of Pediatric Gastroenterology and Nutrition, vol. 52, no. 1, pp. 65–72, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. U. Protzer, H. P. Dienes, L. Bianchi et al., “Post-infantile giant cell hepatitis in patients with primary sclerosing cholangitis and autoimmune hepatitis,” Journal of Liver, vol. 16, no. 4, pp. 274–282, 1996. View at Publisher · View at Google Scholar · View at Scopus
  19. S. T. L. Micchelli, D. Thomas, J. K. Boitnott, and M. Torbenson, “Hepatic giant cells in hepatitis C virus (HCV) mono-infection and HCV/HIV co-infection,” Journal of Clinical Pathology, vol. 61, no. 9, pp. 1058–1061, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. A. Moreno, A. Moreno, M. J. Pérez-Elías et al., “Syncytial giant cell hepatitis in human immunodeficiency virus-infected patients with chronic hepatitis C: 2 cases and review of the literature,” Human Pathology, vol. 37, no. 10, pp. 1344–1349, 2006. View at Publisher · View at Google Scholar · View at Scopus
  21. Ö. Harmanci, I. K. Önal, O. Ersoy, B. Gürel, C. Sökmensüer, and Y. Bayraktar, “Postinfantile giant cell hepatitis due to hepatitis E virus along with the presence of autoantibodies,” Digestive Diseases and Sciences, vol. 52, no. 12, pp. 3521–3523, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. L. Potenza, M. Luppi, P. Barozzi et al., “HHV-6A in syncytial giant-cell hepatitis,” The New England Journal of Medicine, vol. 359, no. 6, pp. 593–602, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. A. Garioud, C. Bachmeyer, A. Cazier et al., “Postinfantile giant cell hepatitis with autoimmune features triggered by primary cytomegalovirus infection in a pregnant woman,” Journal of Clinical Gastroenterology, vol. 50, no. 5, pp. 437-438, 2016. View at Publisher · View at Google Scholar · View at Scopus
  24. M. J. Phillips, L. M. Blendis, S. Poucell et al., “Syncytial giant-cell hepatitis: Sporadic hepatitis with distinctive pathological features, a severe clinical course, and paramyxoviral features,” The New England Journal of Medicine, vol. 324, no. 7, pp. 455–460, 1991. View at Publisher · View at Google Scholar · View at Scopus
  25. P. Kinra and B. M. John, “Hepatitis—a induced non infantile giant cell hepatitis,” Medical Journal Armed Forces India, vol. 63, no. 2, pp. 182-183, 2007. View at Publisher · View at Google Scholar · View at Scopus
  26. M. Fraquelli, A. Colli, M. Cocciolo, and D. Conte, “Adult syncytial giant cell chronic hepatitis due to herbal remedy,” Journal of Hepatology, vol. 33, no. 3, pp. 505–508, 2000. View at Publisher · View at Google Scholar · View at Scopus
  27. N. O'Connor, P. I. Dargan, and A. L. Jones, “Hepatocellular damage from non-steroidal anti-inflammatory drugs,” QJM: Monthly Journal of the Association of Physicians, vol. 96, no. 11, pp. 787–791, 2003. View at Publisher · View at Google Scholar · View at Scopus
  28. A. Dierkes-Globisch, R. Schafer, and H. H. Mohr, “Asymptomatic diclofenac-induced acute hepatitis [in German],” DMW—Deutsche Medizinische Wochenschrift, vol. 125, pp. 797–800, 2000. View at Publisher · View at Google Scholar
  29. A. Alexopoulou, M. Deutsch, J. Ageletopoulou et al., “A fatal case of postinfantile giant cell hepatitis in a patient with chronic lymphocytic leukaemia,” European Journal of Gastroenterology & Hepatology, vol. 15, no. 5, pp. 551–555, 2003. View at Publisher · View at Google Scholar · View at Scopus
  30. K. Dohmen, S. Ohtsuka, H. Nakamura et al., “Post-infantile giant cell hepatitis in an elderly female patient with systemic lupus erythematosus,” Journal of Gastroenterology, vol. 29, no. 3, pp. 362–368, 1994. View at Publisher · View at Google Scholar · View at Scopus
  31. M. Gorelik, R. Debski, and H. Frangoul, “Autoimmune hemolytic anemia with giant cell hepatitis: Case report and review of the literature,” Journal of Pediatric Hematology/Oncology, vol. 26, no. 12, pp. 837–839, 2004. View at Google Scholar · View at Scopus
  32. J. Labowitz, S. Finklestein, and M. Rabinovitz, “Postinfantile giant cell hepatitis complicating ulcerative colitis: A case report and review of the literature,” American Journal of Gastroenterology, vol. 96, no. 4, pp. 1274–1277, 2001. View at Publisher · View at Google Scholar · View at Scopus
  33. N. Watanabe, S. Takashimizu, K. Shiraishi et al., “Primary biliary cirrhosis with multinucleated hepatocellular giant cells: Implications for pathogenesis of primary biliary cirrhosis,” European Journal of Gastroenterology & Hepatology, vol. 18, no. 9, pp. 1023–1027, 2006. View at Publisher · View at Google Scholar · View at Scopus
  34. M. Rabinovitz and A. J. Demetris, “Postinfantile giant cell hepatitis associated with anti-M2 mitochondrial antibodies,” Gastroenterology, vol. 107, no. 4, pp. 1162–1164, 1994. View at Publisher · View at Google Scholar · View at Scopus
  35. N. Gupta and B. Njei, “Syncytial giant cell hepatitis in a patient with chronic lymphocytic leukemia,” Journal of Digestive Diseases, vol. 16, no. 11, pp. 683–688, 2015. View at Publisher · View at Google Scholar · View at Scopus
  36. Z. Ben-Ari, E. Broida, Y. Monselise et al., “Syncytial giant-cell hepatitis due to autoimmune hepatitis type II (LKM1 +) presenting as subfulminant hepatitis,” American Journal of Gastroenterology, vol. 95, no. 3, pp. 799–801, 2000. View at Publisher · View at Google Scholar · View at Scopus
  37. J. C. Thus, A. Bosma, S. Henzen-Logmas et al., “Postinfantile giant cell hepatitis in a patient with multiple autoimmune features,” American Journal of Gastroenterology, vol. 80, pp. 294–297, 1985. View at Google Scholar
  38. S. Pittau, S. Morelli, and E. Venturini, “Post-infantile giant cell hepatitis. Clinical and histological response to immunosuppressive therapy,” Recenti Progressi in Medicina, vol. 89, pp. 126–129, 1998. View at Google Scholar
  39. J. Koskinas, M. Deutsch, C. Papaioannou, G. Kafiri, and S. Hadziyannis, “Post-infantile giant cell hepatitis associated with autoimmune hepatitis and polyarteritis nodosa,” Scandinavian Journal of Gastroenterology, vol. 37, no. 1, pp. 120–123, 2002. View at Publisher · View at Google Scholar · View at Scopus
  40. C. J. Fimmel and S. Robertazzi, “Fulminant hepatic failure in an adult patient with giant-cell hepatitis,” Gastroenterol Hepatol (NY), vol. 5, pp. 504–506, 2009. View at Google Scholar
  41. R. H. Krech, V. Geenen, H. Maschek, and B. Högemann, “Adult giant cell hepatitis with fatal course. Clinical pathology case report and reflections on the pathogenesis,” Der Pathologe, vol. 19, no. 3, pp. 221–225, 1998. View at Publisher · View at Google Scholar · View at Scopus
  42. E. Roberts, E. L. Ford-Jones, and M. James Phillips, “Ribavirin for syncytial giant cell hepatitis,” The Lancet, vol. 341, no. 8845, pp. 640-641, 1993. View at Publisher · View at Google Scholar · View at Scopus
  43. S. Nair, B. Baisden, J. Boitnott, A. Klein, and P. J. Thuluvath, “Recurrent, progressive giant cell hepatitis in two consecutive liver allografts in a middle-aged woman,” Journal of Clinical Gastroenterology, vol. 32, no. 5, pp. 454–456, 2001. View at Publisher · View at Google Scholar · View at Scopus
  44. J. P. Lerut, N. Claeys, O. Ciccarelli et al., “Recurrent postinfantile syncytial giant cell hepatitis after orthotopic liver transplantation,” Transplant International, vol. 11, no. 4, pp. 320–322, 1998. View at Publisher · View at Google Scholar · View at Scopus
  45. O. Pappo, E. Yunis, J. A. Jordan et al., “Recurrent and de novo giant cell hepatitis after orthotopic liver transplantation,” The American Journal of Surgical Pathology, vol. 18, no. 8, pp. 804–813, 1994. View at Publisher · View at Google Scholar
  46. F. Durand, C. Degott, A. Sauvanet et al., “Subfulminant syncytial giant cell hepatitis: Recurrence after liver transplantation treated with ribavirin,” Journal of Hepatology, vol. 26, no. 3, pp. 722–726, 1997. View at Publisher · View at Google Scholar · View at Scopus