Time-Course Changes of Serum Keratin Concentrations after Liver Transplantation: Contrasting Results of Keratin-18 and Keratin-19 Fragments

Figure 4

Individual data from Patient 10, who had HCV recurrence after liver transplantation. Liver biopsy (left panels) was performed 3 months after transplantation. (a) Hematoxylin-eosin staining revealed typical signs of HCV recurrence. (b and detail in c) Immunostaining for the M30 neoepitope revealed positivity in apoptotic hepatocytes throughout the liver lobule. (d) Immunostaining for K19 revealed only the normal positivity in bile ducts. Time-course changes in standard biochemical markers (AST, ALT, GGT, and alkaline phosphatase (AP)) and serum keratins (TPS, M30, and CYFRA 21-1) are presented in the right panels. d, day; mo, month.