A Case of Delayed Hepatic Injury Associated with Teriflunomide Use as Assessed for Causality Using the Updated RUCAM

Table 1

Patient LTs and INR over the course of admission.

	AST (units/L)	ALT (units/L)	AP (units/L)	Tbil mg/dL	INR
Reference range	6–58 u/L	14–67 u/L	38–150 u/L	0.3–1.2 mg/dL	1
Admission	1,499	777	478	2.5	1.2
Hospital day 1	842	583	442	3.2
Hospital day 2	527	442	595	4.4
Hospital day 3	403	392	643	5.4
Hospital day 4	368	341	759	6.5	1.37
Hospital day 5	404	361	929	8.6
Hospital day 6	449	402	972	9.7	1.66
Hospital day 7	366	357	894	10	1.97
Hospital day 8	289	323	892	10.9	1.73
Hospital day 9	259	302	919	10.7	1.64
Hospital day 10	232	278	891	9.2
Discharge	170	232	769	7.8
One month follow-up	33	21	355	0.9	1.26

Initiation of cholestyramine.