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Case Reports in Immunology
Volume 2014, Article ID 737453, 3 pages
Case Report

Systemic Lupus Erythematosus with Hepatosplenic Granuloma: A Rare Case

1Department of Pathology, King George Medical University, Lucknow 226003, India
2Department of General Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India

Received 11 August 2014; Revised 29 October 2014; Accepted 8 November 2014; Published 20 November 2014

Academic Editor: Maurizio Benucci

Copyright © 2014 Anju Bharti and Lalit Prashant Meena. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Systemic lupus erythematosus (SLE) is an autoimmune disease which is known to present with a wide variety of clinical manifestations. Case Report. A 15-year-old male presented with complaints of moderate grade fever and generalized body swelling. There was no history of cough, weight loss, joint pain, oral ulcerations, skin rash, photosensitivity, loss of hair, pain abdomen, jaundice, or any significant illness in the past. Contrast enhanced computerized tomography of the abdomen revealed hypodense lesions in both liver and spleen (without contrast enhancement), suggestive of granulomas along with few retroperitoneal and mesenteric lymph nodes. On the basis of immunological tests and renal biopsy report, SLE with hepatosplenic granulomatosis diagnosis was made. He was given pulse methylprednisolone 500 mg, for 3 days and he showed dramatic improvement clinically. Conclusion. Hepatic and splenic granulomas are not common in SLE, but this should be kept in differential diagnosis.