Differential Impairment of Interferon-γ Responses in Two Cases of Pulmonary Nontuberculous Mycobacterial Disease

Figure 1

Box plots of whole blood IFN-γ production to stimulation with IL-12 BCG, phytohaemagglutinin, and IL-18, lipopolysaccharide. Whole blood was incubated with stimuli for 16 hours before supernatant was analysed for IFN-γ. Cases  1 and  2 were sampled at different time points: before commencing IFN-γ (pre-IFN), 3 months into IFN- γ therapy (during IFN), and 6 months after stopping IFN-γ therapy (post-IFN). Control box plot showing mean, interquartile range, and 1 standard deviation (whiskers) based on analysis of 27 healthy controls aged 20–60 yrs. Cases did not have detectable IFN-γ in the absence of stimuli (Supplementary Figure  1).

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