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Case Reports in Immunology
Volume 2017, Article ID 2676403, 9 pages
https://doi.org/10.1155/2017/2676403
Case Report

Necrotizing Liver Granuloma/Abscess and Constrictive Aspergillosis Pericarditis with Central Nervous System Involvement: Different Remarkable Phenotypes in Different Chronic Granulomatous Disease Genotypes

1Pediatric Immunology Department, Medical Faculty, Ege University, Izmir, Turkey
2Interventional Radiology Department, Medical Faculty, Ege University, Izmir, Turkey
3Cardiovascular Surgery Department, Medical Faculty, Ege University, Izmir, Turkey
4Pediatric Cardiology Department, Medical Faculty, Ege University, Izmir, Turkey
5Pediatric Intensive Care Unit, Medical Faculty, Ege University, Izmir, Turkey
6Pediatric Surgery Department, Medical Faculty, Ege University, Izmir, Turkey
7Radiology Department, Medical Faculty, Ege University, Izmir, Turkey
8Pediatric Radiology Department, Medical Faculty, Ege University, Izmir, Turkey

Correspondence should be addressed to Sanem Eren Akarcan; moc.oohay@nerenas

Received 1 November 2016; Accepted 21 December 2016; Published 10 January 2017

Academic Editor: Anne E. Tebo

Copyright © 2017 Sanem Eren Akarcan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Chronic granulomatous disease (CGD) is a primary immune deficiency causing predisposition to infections with specific microorganisms, Aspergillus species and Staphylococcus aureus being the most common ones. A 16-year-old boy with a mutation in CYBB gene coding protein (X-linked disease) developed a liver abscess due to Staphylococcus aureus. In addition to medical therapy, surgical treatment was necessary for the management of the disease. A 30-month-old girl with an autosomal recessive form of chronic granulomatous disease (CYBA gene mutation affecting protein) had invasive aspergillosis causing pericarditis, pulmonary abscess, and central nervous system involvement. The devastating course of disease regardless of the mutation emphasizes the importance of early diagnosis and intervention of hematopoietic stem cell transplantation as soon as possible in children with CGD.