IgG4-Related Sclerosing Disease Causing Spinal Cord Compression: The First Reported Case in Literature

Table 1

Case	Patient Age	Gender	Clinical presentation	Presence of extra-spinal disease	Treatment	Outcome
Chan et al. 2009	37	Male	Bilateral lower extremity weakness, numbness, unsteady gait × 2 weeks	Not reported	Not reported	Not reported
Choi et al. 2010	46	Female	Progressive bilateral lower extremity weakness and numbness × 2 weeks	Not reported	Steroids	Improved exam to ‘near normal’ after initial surgery; progression 2 months post op required second resection (subtotal) with full recovery; no recurrence at 8 months
Lindstrom et al. 2010	55	Male	Cord compression, C3-C7 mass	Not reported	Steroids; Radiation Therapy	“Doing well” at 15 month follow up
Lindstrom et al. 2010	63	Male	Bilateral hand numbness, C2-C3 mass	Not reported	Not reported	Lost to follow-up
Tajima et al. 2012	64	Male	Gradually progressive and worsening dysphagia for 1 month	Slight swelling in both kidneys-renal	Steroids	Improvement of symptoms and MRI findings at 3 weeks
Wallace et al. 2013	32	Male	Weakness of dorsum of right foot	Not reported	Not reported	Lost to follow-up
Ezzeldin et al. 2014	55	Male	Diplegia of lower extremities and T4/T5 sensory level for 2 weeks	Not reported	Steroids	Able to ambulate at discharge (timing not specified)
Kim et al. 2014	52	Female	Sudden weakness of bilateral lower extremities for 2 days; paraplegia, urinary retention	None	Steroids	Unchanged after 2 months
Gu et al. 2016	43	Male	Neck pain for 15 days, bilateral lower extremity numbness/weakness, bowel/bladder dysfunction for 4 days	Patient declined testing	Not reported	Resolution of symptoms at 6 months post-op
Radotra et al. 2016	50	Male	Progressive bilateral lower extremity weakness for 6 months	Not reported	Steroids	Marginal improvement in strength 7 months post-op
Radotra et al. 2016	19	Male	back and left lower extremity pain for 1 year; subtle knee extensor weakness bilaterally	Not reported	Steroids	Pain free at 6 months; stable exam
Ferreira et al. 2016	57	Female	Worsening low back pain for 2.5 years; bilateral lower extremity numbness and weakness	None	Steroids	Recurrence and progressive paresis later improved after third resection and long-term steroids
Lu et al. 2016	55	Male	Diffuse numbness and weakness for 6 months; constipation and dysuria for 7 days	Not reported	Steroids, cyclophosphamide	Recovered defecation/urination at 20 days; ambulated independently at 5 months
Rumalla et al. 2017	50	Male	Rapidly progressive severe back pain at T6 level for 3 months; acute onset paraplegia, T6 sensory level	Right lung associated with adjacent vertebral involvement	Steroids	Near normal lower extremity strength 2 months post-op
Williams et al. 2017	46	Female	Worsening neck pain and bilateral upper extremity paresthesias and weakness for 4 months	Not reported	Steroids, azathioprine	Improving strength at 6 month post-op visit
Bridges et al. 2017	68	Male	Intermittent thoracic spine pain for 3 years, progressive trunk numbness and bilateral lower extremity numbness for 6 months, dysequilibrium	None	Steroids	Walking independently with resolution of pain at 3 months post-op
Winkel et al. 2018	48	Female	Lower back pain, neurogenic claudication, right lower extremity radiculopathy, extradural mass L2-L3 level	None	Steroids	Asymptomatic at 1 year follow-up