Primary Immunodeficiency with Severe Multi-Organ Immune Dysregulation

Table 1

Chronological clinical features.

Condition	Age
Oral thrush	9 months
Pancreatic insufficiency	2 years
Adrenal insufficiency	3
Uveitis	4
Candidal onychomycosis	5
Enteropathy	6
Alopecia	7
Raynaud’s disease	7
Vitiligo	8
Sjogren’s syndrome	10
Hypoparathyroidism	11
Hypothyroidism	12
Gastroparesis	12
Nasal polyps, recurrent	12
Aural polyp	12
Megacolon	12
Autoimmune hepatitis	15