On Two Cases with Autosomal Dominant Hyper IgE Syndrome: Importance of Immunological Parameters for Clinical Course and Follow-Up

Table 2

Evaluation of STAT3 signaling pathway activation in patients.

Individuals tested	STAT3 activation in CD4+		STAT3 activation in CD8+
Patient 1	CD4+ (U) Geo MFI	5	CD8+ (U) Geo MFI	5
	CD4+ (S) Geo MFI	16	CD8+ (S) Geo MFI	17
	Geo MFI index	3.2	Geo MFI index	3.4
Healthy control 1	CD4+ (U) Geo MFI	7	CD8+ (U) Geo MFI	5
	CD4+ (S) Geo MFI	42	CD8+ (S) Geo MFI	40
	Geo MFI index	6	Geo MFI index	8
Patient 2	CD4+ (U) Geo MFI	13	CD8+ (U) Geo MFI	9
	CD4+ (S) Geo MFI	32	CD8+ (S) Geo MFI	37
	Geo MFI index	2.5	Geo MFI index	4.1
Healthy control 2	CD4+ (U) Geo MFI	139	CD8+ (U) Geo MFI	170
	CD4+ (S) Geo MFI	901	CD8+ (S) Geo MFI	971
	Geo MFI index	6.5	Geo MFI index	5.7

U: unstimulated; S: stimulated; Geo MFI: geometric mean fluorescence intensity; Geo MFI index: ratio of Geo MFI of stimulated to Geo MFI of unstimulated cells.