Case Report
Cerebellar Ataxia Followed by Stiff Person Syndrome in a Patient with Anti-GAD Antibodies
Table 2
Previous studies describing the combination of anti-GAD antibody-associated stiff person syndrome and cerebellar ataxia.
| Reference | Age, sex | Presentation | Associated immunological disorders | Immunotherapy | Response to immunotherapy |
| Giometto et al. [9] | 55, female | SPS ≥ CA | DM1, PA | Steroids | Partial response | Kono et al. [4] | 46, female | CA ≥ SPS | DM1 | NS | — | Kim et al. [3] | 40, female | SPS + CA | DM1, HT | Steroids | Good response | Rakocevic et al. [8] | 30, male | SPS ≥ CA | | IVIG | Partial response | 51, female | CA ≥ SPS | DM1, PA | IVIG, steroids | No response | 72, female | SPS ≥ CA | | IVIG, steroids | No response | 50, male | SPS ≥ CA | DM1, HT | NS | — | 63, male | SPS ≥ CA | PA | IVIG | No response | Ances et al. [10] | 55, female | SPS + CA | — | IVIG | Good response | Schaefer and Moeller [11] | 42, male | SPS + CA ≥ LE | DM1, HT | IVIG and steroids Plasmapheresis and rituximab | No response, good response |
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SPS = stiff person syndrome; CA = cerebellar ataxia; LE = limbic encephalitis; DM1 = type-1 diabetes mellitus; PA = pernicious anaemia; HT = Hashimoto thyroiditis; IVIG = intravenous immunoglobulin; NS = not specified.
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