Case Report

Cerebellar Ataxia Followed by Stiff Person Syndrome in a Patient with Anti-GAD Antibodies

Table 2

Previous studies describing the combination of anti-GAD antibody-associated stiff person syndrome and cerebellar ataxia.

ReferenceAge, sexPresentationAssociated immunological disordersImmunotherapyResponse to immunotherapy

Giometto et al. [9]55, femaleSPS ≥ CADM1, PASteroidsPartial response
Kono et al. [4]46, femaleCA ≥ SPSDM1NS
Kim et al. [3]40, femaleSPS + CADM1, HTSteroidsGood response
Rakocevic et al. [8]30, maleSPS ≥ CAIVIGPartial response
51, femaleCA ≥ SPSDM1, PAIVIG, steroidsNo response
72, femaleSPS ≥ CAIVIG, steroidsNo response
50, maleSPS ≥ CADM1, HTNS
63, maleSPS ≥ CAPAIVIGNo response
Ances et al. [10]55, femaleSPS + CAIVIGGood response
Schaefer and Moeller [11]42, maleSPS + CA ≥ LEDM1, HTIVIG and steroids
Plasmapheresis and rituximab
No response, good response

SPS = stiff person syndrome; CA = cerebellar ataxia; LE = limbic encephalitis; DM1 = type-1 diabetes mellitus; PA = pernicious anaemia; HT = Hashimoto thyroiditis; IVIG = intravenous immunoglobulin; NS = not specified.