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Case Reports in Infectious Diseases
Volume 2013 (2013), Article ID 190183, 4 pages
http://dx.doi.org/10.1155/2013/190183
Case Report

Legionellosis and Lung Abscesses: Contribution of Legionella Quantitative Real-Time PCR to an Adapted Followup

G. Descours,1,2,3,4,5,6 C. Tellini,7 C. Flamens,8 F. Philit,9 M. Celard,6 J. Etienne,1,2,3,4,5,6 G. Lina,1,2,3,4,5,6 and S. Jarraud1,2,3,4,5,6

1CIRI, International Center for Infectiology Research, Université de Lyon, Lyon, France
2Inserm, U1111, Lyon, France
3Ecole Normale Supérieure de Lyon, Lyon, France
4Université Lyon 1, Centre International de Recherche en Infectiologie, Lyon, France
5CNRS, UMR5308, Lyon, France
6Hospices Civils de Lyon, Groupement Hospitalier Est, Legionella National Reference Center, East Biology & Pathology Center, 59 Boulevard Pinel, 69677 Bron, France
7Centre Hospitalier Pierre Oudot, Biology Laboratory, 30 Avenue du Medipole, 38317 Bourgoin-Jallieu, France
8Hospices Civils de Lyon, Groupement Hospitalier Est, Department of Anesthesiology and Intensive Care, Louis Pradel Hospital, 28 Avenue Doyen Lépine, 69677 Bron, France
9Hospices Civils de Lyon, Groupement Hospitalier Est, Department of Respiratory Medicine, Louis Pradel Hospital, 28 Avenue Doyen Lépine, 69677 Bron, France

Received 18 March 2013; Accepted 19 May 2013

Academic Editors: S. Dogra and L. Yamuah

Copyright © 2013 G. Descours et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We report a case of severe Legionnaires' disease (LD) complicated by a lung abscess in an immunocompetent patient who required ECMO therapy and thoracic surgery. The results of repeated Legionella quantitative real-time PCR performed on both sera and respiratory samples correlated with the LD severity and the poor clinical outcome. Moreover, the PCR allowed for the detection of Legionella DNA in the lung abscess specimen, which was negative when cultured for Legionella. This case report provides a logical basis for further investigations to examine whether the Legionella quantitative PCR could improve the assessment of LD severity and constitute a prognostic marker.