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Case Reports in Infectious Diseases
Volume 2013, Article ID 589490, 4 pages
http://dx.doi.org/10.1155/2013/589490
Case Report

Combination Antifungal Therapy in the Treatment of Scedosporium apiospermum Central Nervous System Infections

Division of Infectious Diseases, University of Colorado Denver, 12700 E. 19th Avenue, Mail Stop B168, Aurora, CO 80045, USA

Received 6 March 2013; Accepted 8 April 2013

Academic Editors: C. L. Gibert and D. L. Palazzi

Copyright © 2013 Andrés F. Henao-Martínez et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Treatment of Scedosporium apiospermum central nervous system (CNS) infection typically consists of an azole in combination with surgical debridement. This approach requires prolonged treatment and carries a high associated mortality. We present two cases of the successful treatment of S. apiospermum CNS infections with the combination of voriconazole and terbinafine.