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Case Reports in Infectious Diseases
Volume 2014, Article ID 234545, 4 pages
Case Report

Cotreatment of Congenital Measles with Vitamin A and Intravenous Immunoglobulin

1Hacettepe University Medical Faculty, Pediatric Infectious Diseases Unit, Sıhhıye, 06100 Ankara, Turkey
2Department of Neonatology, Hacettepe University Faculty of Medicine, Ankara, Turkey
3Turkey Public Health Agency, Virology Reference and Research Laboratory, Ankara, Turkey

Received 10 September 2014; Revised 14 November 2014; Accepted 20 November 2014; Published 7 December 2014

Academic Editor: Daniela M. Cirillo

Copyright © 2014 Yasemin Ozsurekci et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Although the measles vaccine has been part of routine national childhood vaccination programs throughout Europe, measles remains a public health concern. High numbers of cases and outbreaks have occurred throughout the European continent since 2011, and an increasing number of cases have been reported in Turkey since 2012. During a recent measles outbreak in Turkey, 2 pregnant women contracted measles prior to delivering preterm infants at Hacettepe University Hospital. Measles virus genomic RNA and IgM antibodies against measles were detected in the cord blood of infants and mothers in both cases. The infants were treated with intravenous immunoglobulin (IVIG) and vitamin A. Transient thrombocytopenia was present in 1 infant and treated with an additional dose of IVIG and vitamin A. The infants were discharged, without complications, within 10 days of birth. The successful treatment of these cases suggests that infants who have been exposed to, or infected with, measles may benefit from cotreatment of vitamin A and IVIG.