Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Infectious Diseases
Volume 2015, Article ID 284168, 3 pages
http://dx.doi.org/10.1155/2015/284168
Case Report

Ruxolitinib Associated Tuberculosis Presenting as a Neck Lump

ENT Department, Addenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB2 0QQ, UK

Received 26 September 2015; Accepted 9 December 2015

Academic Editor: Sandeep Dogra

Copyright © 2015 Eamon Shamil et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. Colomba, R. Rubino, L. Siracusa et al., “Disseminated tuberculosis in a patient treated with a JAK2 selective inhibitor: a case report,” BMC Research Notes, vol. 5, article 552, 2012. View at Publisher · View at Google Scholar · View at Scopus
  2. E. J. Baxter, L. M. Scott, P. J. Campbell et al., “Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders,” The Lancet, vol. 365, no. 9464, pp. 1054–1061, 2005. View at Publisher · View at Google Scholar
  3. F. Cervantes, A. M. Vannucchi, J.-J. Kiladjian et al., “Three-year efficacy, safety, and survival findings from COMFORT-II, a phase 3 study comparing ruxolitinib with best available therapy for myelofibrosis,” Blood, vol. 122, no. 25, pp. 4047–4053, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. R. Kralovics, F. Passamonti, A. S. Buser et al., “A gain-of-function mutation of JAK2 in myeloproliferative disorders,” The New England Journal of Medicine, vol. 352, no. 17, pp. 1779–1790, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. A. Tefferi, “Primary myelofibrosis: 2012 update on diagnosis, risk stratification, and management,” American Journal of Hematology, vol. 86, no. 12, pp. 1017–1026, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. S. Verstovsek, R. A. Mesa, J. Gotlib et al., “A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis,” The New England Journal of Medicine, vol. 366, no. 9, pp. 799–807, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. S. Verstovsek, H. Kantarjian, R. A. Mesa et al., “Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis,” The New England Journal of Medicine, vol. 363, no. 12, pp. 1117–1127, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. C. Harrison, J.-J. Kiladjian, H. K. Al-Ali et al., “JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis,” The New England Journal of Medicine, vol. 366, no. 9, pp. 787–798, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. R. A. Goldberg, E. Reichel, and L. J. Oshry, “Bilateral toxoplasmosis retinitis associated with ruxolitinib,” The New England Journal of Medicine, vol. 369, no. 7, pp. 681–683, 2013. View at Publisher · View at Google Scholar · View at Scopus
  10. N. G. Wysham, D. R. Sullivan, and G. Allada, “An opportunistic infection associated with ruxolitinib, a novel janus kinase 1,2 inhibitor,” Chest, vol. 143, no. 5, pp. 1478–1479, 2013. View at Publisher · View at Google Scholar · View at Scopus
  11. W. G. Dixon, K. L. Hyrich, K. D. Watson et al., “Drug-specific risk of tuberculosis in patients with rheumatoid arthritis treated with anti-TNF therapy: results from the British Society for Rheumatology Biologics Register (BSRBR),” Annals of the Rheumatic Diseases, vol. 69, no. 3, pp. 522–528, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. J. Askling, C. M. Fored, L. Brandt et al., “Risk and case characteristics of tuberculosis in rheumatoid arthritis associated with tumor necrosis factor antagonists in Sweden,” Arthritis and Rheumatism, vol. 52, no. 7, pp. 1986–1992, 2005. View at Publisher · View at Google Scholar · View at Scopus
  13. R. K. Hopman, S. J. Lawrence, and S. T. Oh, “Disseminated tuberculosis associated with ruxolitinib,” Leukemia, vol. 28, no. 8, pp. 1750–1751, 2014. View at Publisher · View at Google Scholar · View at Scopus
  14. F. Palandri, N. Polverelli, L. Catani, and N. Vianelli, “Ruxolitinib-associated tuberculosis: a case of successful ruxolitinib rechallenge,” Annals of Hematology, vol. 94, no. 3, pp. 519–520, 2015. View at Publisher · View at Google Scholar · View at Scopus
  15. Y. H. Chen, C. H. Lee, and S. N. Pei, “Pulmonary tuberculosis reactivation following ruxolitinib treatment in a patient with primary myelofibrosis,” Leukemia & Lymphoma, vol. 56, no. 5, pp. 1528–1529, 2015. View at Publisher · View at Google Scholar
  16. A. Heine, P. Brossart, and D. Wolf, “Ruxolitinib is a potent immunosuppressive compound: is it time for anti-infective prophylaxis?” Blood, vol. 122, no. 23, pp. 3843–3844, 2013. View at Publisher · View at Google Scholar · View at Scopus