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Case Reports in Infectious Diseases
Volume 2015, Article ID 340725, 3 pages
http://dx.doi.org/10.1155/2015/340725
Case Report

Recurrent Candida albicans Ventriculitis Treated with Intraventricular Liposomal Amphotericin B

Department of Pediatrics, Marmara University School of Medicine, 3500 Istanbul, Turkey

Received 28 May 2015; Revised 20 September 2015; Accepted 27 September 2015

Academic Editor: Paola Di Carlo

Copyright © 2015 Demet Toprak et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Central nervous system (CNS) infection with Candida is rare but significant because of its high morbidity and mortality. When present, it is commonly seen among immunocompromised and hospitalized patients. Herein, we describe a case of a four-year-old boy with acute lymphoblastic leukemia (ALL) who experienced recurrent Candida albicans meningitis. The patient was treated successfully with intravenous liposomal amphotericin B at first attack, but 25 days after discharge he was readmitted to hospital with symptoms of meningitis. Candida albicans was grown in CFS culture again and cranial magnetic resonance imaging (MRI) showed ventriculitis. We administered liposomal amphotericin B both intravenously and intraventricularly and favorable result was achieved without any adverse effects. Intraventricular amphotericin B may be considered for the treatment of recurrent CNS Candida infections in addition to intravenous administration.