Treatment of Immunocompromised, Critically Ill Patients with Influenza A H1N1 Infection with a Combination of Oseltamivir, Amantadine, and Zanamivir

Table 2

Concentrations of oseltamivir (carboxylate) in lung and kidney tissue of the patient in case two. Samples were obtained postmortem and determined using liquid chromatography/tandem mass spectrometry.

	Oseltamivir; (ng/mg tissue)	Oseltamivir carboxylate; (ng/mg tissue)
Left lung	<LLOQ	0.19
Right lung	<LLOQ	0.155
Left kidney	0.06	4.53
Right kidney	0.04	3.69

<LLOQ = less than the lower limit of quantification (= 0.015 ng/mg for oseltamivir).