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Case Reports in Infectious Diseases
Volume 2015, Article ID 857539, 3 pages
Case Report

Neuroinvasive Cryptococcosis in an Immunocompetent Patient with a Negative Spinal Fluid Cryptococcus Antigen

1Department of Neurology, Mount Sinai Beth Israel, New York, NY 10003, USA
2Department of Infectious Diseases, Mount Sinai Beth Israel, New York, NY 10003, USA

Received 21 January 2015; Accepted 3 April 2015

Academic Editor: Wirongrong Chierakul

Copyright © 2015 Rocio C. Garcia-Santibanez et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


58-year-old man presented with headache, nausea, vomiting, and gait disturbance. Brain MRI showed meningeal enhancement and herniation. Serum Cryptococcus antigen was positive but spinal fluid antigen and cultures were negative. A cerebellar biopsy revealed nonencapsulated Cryptococcus. He completed antifungal therapy. Serum Cryptococcus antigen titer decreased. He had a full neurological recovery.