Treatment of Polymicrobial Osteomyelitis with Ceftolozane-Tazobactam: Case Report and Sensitivity Testing of Isolates

Table 1

Ratio of ceftolozane concentrations between bone tissue and plasma.

	Dose	Time after last dose (hours)	Bone : serum concentration ratio
Rabbit model	1 g q 8 h	1.5	Marrow: 14.1%–17.5%; Bone: 6.2%–9.0%
Rat model	20 mg/kg	2	27%
		8	40%

Source: unpublished manufacturer data.