Case Reports in Infectious Diseases / 2016 / Article / Tab 1

Case Report

Treatment of Polymicrobial Osteomyelitis with Ceftolozane-Tazobactam: Case Report and Sensitivity Testing of Isolates

Table 1

Ratio of ceftolozane concentrations between bone tissue and plasma.

DoseTime after last dose (hours)Bone : serum concentration ratio

Rabbit model1 g q 8 h1.5Marrow: 14.1%–17.5%
Bone: 6.2%–9.0%
Rat model20 mg/kg227%
840%

Source: unpublished manufacturer data.

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