Case Reports in Infectious Diseases / 2016 / Article / Tab 2

Case Report

Treatment of Polymicrobial Osteomyelitis with Ceftolozane-Tazobactam: Case Report and Sensitivity Testing of Isolates

Table 2

Bone penetration of cephalosporins and β-lactamase inhibitors [12].

Time after last dose (hours)Bone (mg/kg): serum concentration (mg/L) ratioMethod

Cephalosporins
Ceftriaxone0.2–80.07–0.17HPLC
Cefotaxime 0.75–40.02–0.28Bioassay
Cefuroxime (osteomyelitis)10.04–0.08HPLC
Cefazolin0.90.179HPLC
Cefepime1-20.46–0.76HPLC
Ceftazidime (ischemic bone)1-20.04–0.08HPLC
Ceftazidime20.54Bioassay

β-Lactamase inhibitors
Clavulanic acid11.14–1.76Bioassay
Sulbactam0.25–40.17–0.71Gas chromatography
Tazobactam1.50.22–0.26HPLC

Assumed bone density of 1 kg/L was assumed if not reported.
HPLC: high-performance liquid chromatography.

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