Disseminated Cryptococcal Disease in Non-HIV, Nontransplant Patient

Table 2

Review of HIV negative disseminated cryptococcal case reports.

Age	Sex	Underlying condition	Presentation	Microbiology	Treatment	Outcome	References
62	Male	Renal transplant on cyclosporine, azathioprine, and prednisone	Miliary pulmonary cryptococcus	Positive blood cultures	Fluconazole	Did well and stable	[14]
43	Male	Renal transplant on cyclosporine, mycophenolate mofetil, and prednisone	Cellulitis	Positive blood cultures	Amphotericin lipid complex at 6 mg/Kg for 2 weeks and then fluconazole for 3 months	No recurrence at 4-month follow-up	[15]
34	Male	Nephrotic syndrome on prednisone	Bilateral LL ulcers	Blood, sputum, and biopsy cultures	Fluconazole	Death	[16]
26	Female	No significant past history	Crohn’s disease	Colon and sputum	Fluconazole for 5 weeks	Improved	[17]
7	Male	No significant past history	Hepatosplenomegaly, LAP, bilateral choroiditis, and skin lesions	Blood, CSF, and skin biopsy cultures	Amphotericin and fluconazole	Remission	[18]
79	Male	COPD and CAD	Splenomegaly, LAP, and respiratory symptoms	Sputum cultures and bone marrow PCR	Amphotericin and fluconazole	Death	[19]
28	Male	No significant past history	Hepatosplenomegaly, LAP, and lymphopenia	Lymph node biopsy culture	Amphotericin and fluconazole	Death	[20]
70	Male	No significant past history	Thigh nodule, chest, and brain lesions	Biopsy of thigh nodule and sputum cultures	Amphotericin and; fluconazole	Resolution of his symptoms and lesions at 1-year follow-up	[21]
65	Female	NHL on CHOP- rituximab	Meningitis and respiratory symptoms	Blood, pleural fluid, and CSF cultures	Amphotericin, flucytosine, and; fluconazole	Remission	[22]
63	Male	Diabetes mellitus, AHA-steroid, and splenectomy	Headache, photophobia, decreased vision, panuveitis, and lung/brain lesions	Lung biopsy culture	Amphotericin, flucytosine, and; fluconazole for 1 year	Improved	[23]

LAP, lymphadenopathy; NHL, non-Hodgkin’s lymphoma; CHOP, C: cyclophosphamide, H: doxorubicin hydrochloride (adriamycin), and O: vincristine (Oncovin); PCR, polymerase chain reaction; mg, milligrams; Kg, kilograms.