Typical Facial Lesions: A Window of Suspicion for Progressive Disseminated Histoplasmosis—A Case of Asian Prototype

Figure 2

Skin biopsy shows a dense dermal histiocytic infiltrate with the presence of numerous intracellular spherical organisms surrounded by a halo in histiocytes, hematoxylin and eosin (H&E): (a) ×400 and (b) ×1000. These organisms stained positive with periodic acid Schiff (c) ×1000 and silver methenamine (d) ×1000 stains. All are morphologically compatible with Histoplasma as focused with arrows.

(a)

(b)

(c)

(d)