Typical Facial Lesions: A Window of Suspicion for Progressive Disseminated Histoplasmosis—A Case of Asian Prototype

Figure 3

Liver biopsy shows numerous spherical organisms in the sinusoidal macrophages and Kupffer cells, (a) H&E ×1000, which stained positive with periodic acid Schiff stain (b) ×1000. Similar organisms are also seen in interstitial histiocytes in lung, (c) H&E ×1000, and splenic macrophages, (d) H&E ×1000. All are morphologically compatible with Histoplasma as focused with arrows.

(a)

(b)

(c)

(d)