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Case Reports in Infectious Diseases
Volume 2016, Article ID 3242196, 3 pages
Case Report

Voriconazole-Induced Periostitis Mimicking Chronic Graft-versus-Host Disease after Allogeneic Stem Cell Transplantation

1Department of Pharmacy Practice, University of Illinois at Chicago, Chicago, IL 60612, USA
2Cancer Center, University of Illinois, Chicago, IL 60612, USA
3Division of Hematology/Oncology, University of Illinois at Chicago, Chicago, IL 60612, USA

Received 30 March 2016; Accepted 24 May 2016

Academic Editor: Pere Domingo

Copyright © 2016 Karen Sweiss et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Voriconazole is an established first-line agent for treatment of invasive fungal infections in patients undergoing allogeneic stem cell transplantation (ASCT). It is associated with the uncommon complication of periostitis. We report this complication in a 58-year-old female undergoing HSCT. She was treated with corticosteroids with minimal improvement. The symptoms related to periostitis can mimic chronic graft-versus-host disease in patients undergoing HSCT and clinicians should differentiate this from other diagnoses and promptly discontinue therapy.