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Case Reports in Infectious Diseases
Volume 2016, Article ID 8915047, 2 pages
Case Report

Rituximab-Associated Inflammatory Progressive Multifocal Leukoencephalopathy

Madigan Army Medical Center, Tacoma, WA, USA

Received 5 July 2016; Revised 14 September 2016; Accepted 20 October 2016

Academic Editor: Jean-François Faucher

Copyright © 2016 Chandra Punch et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Progressive multifocal leukoencephalopathy (PML) is a rare disease of the immunosuppression that results from neurotropic invasion of the JC virus which leads to demyelination of oligodendrocytes. Immune reconstitution inflammatory syndrome (IRIS), on the other hand, is a condition of inflammation that develops as the immune system reconstitutes. This case report describes a case of a 35-year-old HIV-negative male who presented with three weeks of right lower extremity paresthesias as well as right upper extremity apraxia. He was diagnosed with PML complicated by IRIS secondary to Rituximab, which he had completed four months prior to presentation. Despite the condition’s poor prognosis, the patient recovered with only minor deficits.