Nicolau Syndrome due to Penicillin Injection: A Report of 3 Cases without Long-Term Complication

Figure 1

A 2-year-old girl with Nicolau syndrome after injection of benzathine penicillin. (a) The right leg and foot are pale and mottled with ecchymosis and the necrosis of the second toe. (b) Mottling and ecchymosis of the plantar surface and toes of the right foot and the necrotic toes. (c) A round ulcer with about 2-centimeter diameter, on the right labia major. (d) At 2 months’ follow-up improvement of the skin ecchymosis was noticed, but a persistent necrosis lesion in the distal phalanges of some of the toes appeared.

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