Use of Next Generation Sequencing and Synergy Susceptibility Testing in Diagnosis and Treatment of Carbapenem-Resistant Klebsiella pneumoniae Blood Stream Infection

Table 1

The top five drug resistant and virulence genes of this strain Klebsiella pneumoniae.

Gene names	Protein	Percentage	Depth
Drug resistance gene
KPC-2	Carbapenem-hydrolyzing class A beta-lactamase, KPC-2	100	230
aadA2	ANT(3″)-Ia family aminoglycoside nucleotidyltransferase	100	220
CTX-M-24	Class A extended-spectrum beta-lactamase, CTX-M-24	100	180
QnrS1	Quinolone resistance pentapeptide repeat protein, QnrS1	100	180
dfrA12	Trimethoprim-resistant dihydrofolate reductase, DfrA12	100	180
Virulence gene
bla	Methylmalonic aciduria type A protein	100	1400
fepA	Ferrienterobactin receptor	100	810
mrkD	Fimbria adhesin protein	100	810
iutA	Putative ferric siderophore receptor	100	650
manB	Mannosidase, beta A, lysosomal-like	100	590

Annotation of drug resistance gene: KPC-2, carbapenem-hydrolyzing class A; aadA2, aminoglycoside resistance; CTX-M-24, beta-lactamase class A; QnrS1, quinolone resistance pentapeptide repeat protein; dfrA12, dihydrofolate reductase (trimethoprim resistance protein).