In Vivo Resistance to Ceftolozane/Tazobactam in Pseudomonas aeruginosa Arising by AmpC- and Non-AmpC-Mediated Pathways

Table 2

Summary of amino acid changes in C/T-resistant compared to C/T-susceptible P. aeruginosa.

Strain	Predicted gene product	Predicted amino acid change	Comments
PA2428^a	AmpD	Val10 ⟶ Gly	N-Acetylmuramoyl-L-alanine amidase
	AmpC	Val213 ⟶ Ala	β-Lactamase
	DacB	Gly87 ⟶ Asp	D-Alanyl-D-alanine carboxypeptidase
HOU2366^b	MexR	Lys67 ⟶ Glu	Transcriptional regulator
	AmpC	Δ21 bp 210-216	β-Lactamase
	DUF	Asp265 ⟶ Ala	Predicted signal transduction protein
	PuuA	Leu236 ⟶ Pro	Gamma-glutamyl-putrescine synthetase

^aCompared to C/T-susceptible PA2312; ^bcompared to C/T-susceptible HOU2365.