Case Reports in Infectious Diseases / 2018 / Article / Tab 2

Case Report

In Vivo Resistance to Ceftolozane/Tazobactam in Pseudomonas aeruginosa Arising by AmpC- and Non-AmpC-Mediated Pathways

Table 2

Summary of amino acid changes in C/T-resistant compared to C/T-susceptible P. aeruginosa.

StrainPredicted gene productPredicted amino acid changeComments

PA2428aAmpDVal10 ⟶ GlyN-Acetylmuramoyl-L-alanine amidase
AmpCVal213 ⟶ Alaβ-Lactamase
DacBGly87 ⟶ AspD-Alanyl-D-alanine carboxypeptidase

HOU2366bMexRLys67 ⟶ GluTranscriptional regulator
AmpCΔ21 bp 210-216β-Lactamase
DUFAsp265 ⟶ AlaPredicted signal transduction protein
PuuALeu236 ⟶ ProGamma-glutamyl-putrescine synthetase

aCompared to C/T-susceptible PA2312; bcompared to C/T-susceptible HOU2365.

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