An Immunocompetent HIV-Negative Elderly Patient with Low-Grade Fever, Generalized Lymphadenopathy, Splenomegaly, and Acute Phase Response: Do Not Forget Castleman Disease

<div>Hematoxylin and eosin stain, original magnification ×10. Germinal centers traversed by penetrating vessels (arrow 1) and thickened mantle zones with lymphocytes arranged in layers with onion skin appearance (arrow 2). In the interfollicular areas, there is extensive vascular proliferation with perivascular hyalinization (arrow 3).</div>

Case Reports in Infectious Diseases

fig1

Figure 1

Figure 1: An Immunocompetent HIV-Negative Elderly Patient with Low-Grade Fever, Generalized Lymphadenopathy, Splenomegaly, and Acute Phase Response: Do Not Forget Castleman Disease 

Figure 1 | An Immunocompetent HIV-Negative Elderly Patient with Low-Grade Fever, Generalized Lymphadenopathy, Splenomegaly, and Acute Phase Response: Do Not Forget Castleman Disease 