Lenacapavir with Fostemsavir in a Multidrug-Resistant HIV-Infected Hemodialysis Patient

Table 1

Evolution of the viral resistances according to time.

Sample dates	28 December 2005	31 January 2007	11 January 2008	13 September 2008	14 January 2009	26 July 2010	20 October 2011	09 September 2016	19 May 2017	05 March 2021	Cumulative
Viral load (copies/mL)	67000	>100000	>100000	31000	63300	34300	563	572000	398000	20200
CD4 count (/μL)	488	109	141	203	173	383	336	11	13	591
NRTI
Lamivudine (3TC)	ILL	S	ILL	R	—	—	ILL	S	R	R	R
Abacavir (ABC)	R	IR	R	R	—	—	R	ILL	IR	IR	R
Zidovudine (AZT)	R	R	R	R	—	—	R	IR	IR	R	R
Stavudine (D4T)	R	R	R	R	—	—	R	IR	IR	R	R
Didanosine (DDI)	R	R	R	R	—	—	R	IR	R	R	R
Emtricitabine (FTC)	ILL	S	ILL	R	—	—	ILL	S	R	R	R
Tenofovir (TDF)	R	IR	R	IR	—	—	R	ILL	S	SP	R
NNRTI
Doravirine (DOR)	S	S	S	S	—	—	SP	IR	IR	ILL	IR
Efavirenz (EFV)	S	S	S	S	—	—	IR	R	R	R	R
Etravirine (ETR)	S	S	S	S	—	—	IR	IR	IR	IR	IR
Nevirapine (NVP)	S	S	S	S	—	—	R	R	R	R	R
Rilpivirine (RPV)	S	S	S	S	—	—	IR	R	R	IR	R
PI
Atazanavir (ATV/r)	R	S	R	R	—	—	R	R	R	R	R
Darunavir (DRV/r)	ILL	S	ILL	ILL	—	—	ILL	R	R	R	R
Fosamprenavir (FPV/r)	R	S	R	R	—	—	R	R	R	R	R
Indinavir (IDV/r)	R	S	R	R	—	—	R	R	R	R	R
Lopinavir (LPV/r)	R	S	R	R	—	—	R	R	R	R	R
Nelfinavir (NFV)	R	S	R	R	—	—	R	R	R	R	R
Ritonavir (/r)	R	S	R	R	—	—	R	R	R	R	R
Saquinavir (SQV/r)	R	S	R	R	—	—	R	R	R	R	R
Tipranavir (TPV/r)	R	S	R	R	—	—	R	R	R	R	R
INSTI
Bictegravir (BIC)	—	—	—	—	—	S	S	SP	SP	SP	SP
Cabotegravir (CAB)	—	—	—	—	—	S	S	ILL	ILL	ILL	ILL
Dolutegravir (DTG)	—	—	—	—	—	S	S	SP	SP	SP	SP
Elvitegravir (EVG)	—	—	—	—	—	S	S	IR	IR	IR	IR
Raltegravir (RAL)	—	—	—	—	—	S	S	R	R	R	R
Attachment inhibitors
Maraviroc (MVC)	—	—	—	—	CXCR4 use (phenotypic)	—	—	—	CCR5 use (FPR 17%)	CXCR4 use (FPR 0.1%)	—

INSTI: integrase strand transfer inhibitor, NNRTI: non-nucleoside reverse transcriptase inhibitors, NRTI: nucleoside reverse transcriptase inhibitors, PI: protease inhibitor; ILL: low-level resistance, IR: intermediate resistance, R: high-level resistance, S: susceptible, SP: potential low-level resistance, —: result not available. HD: hemodialysis, PD: peritoneal dialysis, eGFR: estimated glomerular filtration rate, IU: international unit, PA: alkaline phosphatase, Hb: hemoglobin, cp/ml: copies/milliliter, SC: subcutaneous.